The University of Cambridge today confirmed plans to begin trials of a potential new vaccine not only against COVID-19 but all coronaviruses that may spill over from animals to humans in the future.
The new vaccine candidate, DIOS-CoVax2, uses banks of genetic sequences of all known coronaviruses, including those from bats, believed to be the natural hosts of many relatives of human coronaviruses.
“Our approach involves 3D computer modelling of the SARS-CoV-2 [Covid-19] virus” structure. It uses information on the virus itself as well as its relatives – SARS, MERS and other coronaviruses carried by animals that threaten to ‘spill-over” to humans again to cause future human epidemics,” said Professor Jonathan Heeney, head of the Laboratory of Viral Zoonotics at the University of Cambridge, and founder of DIOSynVax – a Cambridge spin-out company.
“We’re looking for chinks in its armour, crucial pieces of the virus that we can use to construct the vaccine to direct the immune response in the right direction. Ultimately we aim to make a vaccine that will not only protect from SARS-CoV-2, but also other related coronaviruses that may spill over from animals to humans,” he said.
Prof Heeney said his team”s strategy involves targeting those domains of the virus” structure that are absolutely critical for docking with a cell, while avoiding the parts that could make things worse.
His team have developed libraries of computer-generated antigen structures encoded by synthetic genes that can train the human immune system to target key regions of the virus and to produce beneficial anti-viral responses.
The team say their proposed new vaccine can be freeze-dried as a powder and is therefore heat stable, meaning that it does not need to be cold-stored. This makes transport and storage much more straightforward, particularly important in low and middle income countries, and it can be delivered through PharmaJet Tropis intradermal Needle-free Injection System, which delivers the vaccine in less than a 1/10th of a second jet injection.
Total number of case in world : Coronavirus Cases: 24,652,652
Total recovery: 17,110,370
Total Death: 17,110,370